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Greater engagement in pleasant leisure activities was associated with lowered caregivers' blood pressure over time," according to the report by Brent T. Mausbach, PhD, of University of California San Diego and colleagues. "Participation in pleasant leisure activities may have cardiovascular benefits for Alzheimer's caregivers." The study included 126 caregivers enrolled in the UCSD Alzheimer's Caregiver Study, a follow-up study evaluating associations between stress, coping, and cardiovascular risk in Alzheimer's caregivers. The caregivers were 89 women and 37 men, average age 74 years, providing in-home care for a spouse with Alzheimer's disease. As part of annual interviews over five years, the caregivers provided information on how often they engaged in various pleasant leisure activities. These ratings were analyzed for association with blood pressure over time, with adjustment for demographic and health factors. The caregivers reported hi...

In a recent feasibility study, clinician-scientists at Beth Israel Deaconess Medical Center (BIDMC) tested an anti-epileptic drug for its potential impact on the brain activity of patients with mild Alzheimer's disease. The team, led by Daniel Z. Press, MD, of the Berenson-Allen Center for Non-invasive Brain Stimulation at BIDMC, documented changes in patients' EEGs that suggest the drug could have a beneficial effect. The research was published in the  Journal of Alzheimer's Disease . "In the field of Alzheimer's disease research, there has been a major search for drugs to slow its progression," said Press, an Instructor of Neurology in the Cognitive Neurology Unit at BIDMC and an Associate Professor of Neurology at Harvard Medical School. "If this abnormal electrical activity is leading to more damage, then suppressing it could potentially slow the progression of the disease." In this double-blind within-subject study, a small group of patie...

After performing a biopsy on the patient, the skin cells are transformed into brain cells that effectively imitate the disease and the age of the patient . The fact that the cells can now be produced in large quantities enables researchers to carry out a series of experiments that were previously not possible. A few years ago, Malin Parmar's research team was one of the first in the world to convert human skin cells directly into brain cells without passing the stem cell state. The discovery shocked the researchers and was perceived as almost impossible. The team is now approaching a point where the discovery is about to bear fruit on a wide scale. By following a new method that involves slightly changing the genetic code that triggers cell conversion, the researchers were able to multiply the production of disease-specific brain cells. "Primarily, we inhibited a protein, REST, involved in establishing identity in cells that are not nerve cells. After limiting this prot...

In a new article published in the journal  Trends in Neurosciences , University of Arizona researchers suggest that the link between exercise and the brain is a product of our evolutionary history and our past as hunter-gatherers. UA anthropologist David Raichlen and UA psychologist Gene Alexander, who together run a research program on exercise and the brain, propose an "adaptive capacity model" for understanding, from an evolutionary neuroscience perspective, how physical activity impacts brain structure and function. Their argument: As humans transitioned from a relatively sedentary apelike existence to a more physically demanding hunter-gatherer lifestyle, starting around 2 million years ago, we began to engage in complex foraging tasks that were simultaneously physically and mentally demanding, and that may explain how physical activity and the brain came to be so connected. "We think our physiology evolved to respond to those increases in physical activity ...